Understanding the basis for differences in both drug responses forms the basis for treatment selection in psychiatric disorders. This course will explore and expand knowledge and applications of: (a) why specific medications may have a therapeutic benefit for some, but not all individuals; (b) why some medications lead to adverse effects in some, but not all individuals; (c) genetic polymorphisms of neurotransmitter-associated proteins including enzymes, transporters and receptors that mediate chemical neurotransmission, and the possible role of these alterations in the manifestation of behavioral disorders; and (d) the latest advances in our understanding of the mechanisms of action of drugs used for the treatment of psychiatric disorders.

Goals and Objectives

The goals and objectives of this course are to complement the basic and clinical information gained during the first three years of medical school and provide students a solid understanding of both pharmacogenomics and neuropsychopharmacology. Specifically, the course is designed to: (a) provide an understanding of the interactions between genetic inheritance, drug actions and the body’s response to drugs; and, (b) explore how recent advances in neuroscience have provided new constructs for understanding the mechanisms mediating the therapeutic effects of current psychoactive drugs.A working knowledge of how pharmacological treatments can be tailored and adapted to the individual is essential for understanding personalized medical approaches to the treatment of psychiatric disorders.

Evaluation

Students will be evaluated based on faculty evaluation of interaction, participation, and presentation on a current issue in pharmacogenomics.

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